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During its maturation, the megakaryocyte grows in size and replicates its DNA without cytokinesis in a process called endomitosis. As a result, the nucleus of the megakaryocyte can become very large and lobulated, which, under a light microscope, can give the false impression that there are several nuclei.
During thrombopoiesis, the promegakaryocyte matures into the form of a megakaryocyte. From the megakaryocyte, platelets are formed. [1] The megakaryoblast is the beginning of the thrombocytic series or platelet forming series. Megakaryoblasts typically have a large oval-shaped nucleus or a nucleus that is lobed with many nuclei. [2]
Ancient history – Aggregate of past events from the beginning of recorded human history and extending as far as the Early Middle Ages or the Postclassical Era. The span of recorded history is roughly five thousand years, beginning with the earliest linguistic records in the third millennium BC in Mesopotamia and Egypt .
The timeline of the evolutionary history of life represents the current scientific theory outlining the major events during the development of life on planet Earth. Dates in this article are consensus estimates based on scientific evidence , mainly fossils .
The timeline of human evolution outlines the major events in the evolutionary lineage of the modern human species, Homo sapiens, throughout the history of life, beginning some 4 billion years ago down to recent evolution within H. sapiens during and since the Last Glacial Period.
In order to eventually produce a megakaryocyte, the haematopoietic stem cell must generate myeloid cells, so it becomes a common myeloid progenitor, CFU-GEMM. This in turn develops into CFU-Meg, which is the colony forming unit that leads to the production of megakaryocytes. [1] [2] [3] Some sources prefer the term "CFU-Mega". [4]
Promegakaryocyte. A promegakaryocyte is a precursor cell for a megakaryocyte, the development of which proceeds as follows: [1]. CFU-Meg (hematopoietic stem cell/hemocytoblast) → megakaryoblast → promegakaryocyte → megakaryocyte
These timelines of world history detail recorded events since the creation of writing roughly 5000 years ago to the present day. For events from c. 3200 BC – c. 500 see: Timeline of ancient history; For events from c. 500 – c. 1499, see: Timeline of post-classical history; For events from c. 1500, see: Timelines of modern history