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Thyroid hormone binding ratio (THBR) is a thyroid function test that measures the "uptake" of T3 or T4 tracer by thyroid-binding globulin (TBG) in a given serum sample. This provides an indirect and reciprocal estimate of the available binding sites on TBG within the sample. The results are then reported as a ratio to normal serum.
Due to the very low concentration of T 4 and T 3 in the blood, TBG is rarely more than 25% saturated with its ligand. Unlike transthyretin and albumin, TBG has a single binding site for T 4 /T 3. TBG is synthesized primarily in the liver as a 54-kDa protein. In terms of genomics, TBG is a serpin; however, it has no inhibitory function like many ...
Decreased thyroxine-binding globulin occurs following bypass surgery, and in chronic illness, a less effective form of TBG with lower affinity for thyroxine is synthesized. Reduced quantities of bound thyroid result, leading to decreased total thyroid measurements.
Thyroid hormone uptake (T uptake or T 3 uptake) is a measure of the unbound thyroxine binding globulins in the blood, that is, the TBG that is unsaturated with thyroid hormone. [2] Unsaturated TBG increases with decreased levels of thyroid hormones. It is not directly related to triiodothyronine, despite the name T 3 uptake. [2] Reference ranges:
Thyroxine-binding globulin (TBG) is a glycoprotein that has a higher affinity for T 4 than for T 3. Transthyretin is also a glycoprotein, but only carries T 4, with hardly any affinity at all for T 3. Finally, both hormones bind with a low affinity to serum albumin, but, due to the large availability of albumin, it has a high capacity.
Thyroid disease is a medical condition that affects the structure and/or function of the thyroid gland.The thyroid gland is located at the front of the neck and produces thyroid hormones [1] that travel through the blood to help regulate many other organs, meaning that it is an endocrine organ.
Taylor Swift is known for writing autobiographical lyrics about specific people that are or used to be in her orbit. In her song “Bad Blood,” she sends a vindictive message to an ex-friend who ...
T3 and TSH are essential for the regulation of cardiac electrical activity. [43] Prolonged ventricular repolarization and atrial fibrillation are often seen in hypothyroidism. [43] The thyroid gland is the only source of thyroid hormone in the body; the process requires iodine and the amino acid tyrosine.