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Apremilast, sold under the brand name Otezla among others, is a medication for the treatment of certain types of psoriasis and psoriatic arthritis. [4] The drug acts as a selective inhibitor of the enzyme phosphodiesterase 4 (PDE4). [ 4 ]
The Seniors (sometimes The Senior or simply Seniors) is a 1978 American comedy film about four college seniors who open a bogus sex clinic, which unexpectedly mushrooms into a multimillion-dollar business.
Seniors is a 2011 Indian Malayalam-language comedy thriller film directed by Vysakh and written by Sachi-Sethu. The plot follows four friends who return to their alma mater as students. It stars Jayaram, Kunchacko Boban, Biju Menon, and Manoj K. Jayan. The film features songs by Alphons Joseph, Jassie Gift, and Alex Paul and a score by Gopi Sundar.
(+)-Desmetramadol is a G-protein biased μ-opioid receptor full agonist. [5] It shows comparatively far lower affinity for the δ-and κ-opioid receptors. [6] The two enantiomers of desmetramadol show quite distinct pharmacological profiles; [7] both (+) and (−)-desmetramadol are inactive as serotonin reuptake inhibitors, [8] but (−)-desmetramadol retains activity as a norepinephrine ...
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In pharmacokinetics, a loading dose is an initial higher dose of a drug that may be given at the beginning of a course of treatment before dropping down to a lower maintenance dose. [ 1 ] A loading dose is most useful for drugs that are eliminated from the body relatively slowly, i.e. have a long systemic half-life .
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