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C3a is one of the proteins formed by the cleavage of complement component 3; the other is C3b. C3a is a 77 residue anaphylatoxin that binds to the C3a receptor (C3aR), a class A G protein-coupled receptor. It plays a large role in the immune response. C3a molecules induce responses through the GPCR C3a receptor.
A-fragments form distinct structural domains of approximately 76 amino acids, coded for by a single exon within the complement protein gene. The C3a, C4a and C5a components are referred to as anaphylatoxins: [4] [5] they cause smooth muscle contraction, vasodilation, histamine release from mast cells, and enhanced vascular permeability. [5]
12266 Ensembl ENSG00000125730 ENSMUSG00000024164 UniProt P01024 P01027 RefSeq (mRNA) NM_000064 NM_009778 RefSeq (protein) NP_000055 NP_033908 Location (UCSC) Chr 19: 6.68 – 6.73 Mb Chr 17: 57.51 – 57.54 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Complement component 3, often simply called C3, is a protein of the immune system that is found primarily in the blood. It plays a ...
Scheme of the complement system. The complement system, also known as complement cascade, is a part of the humoral, innate immune system and enhances (complements) the ability of antibodies and phagocytic cells to clear microbes and damaged cells from an organism, promote inflammation, and attack the pathogen's cell membrane. [1]
Which U.S. state has the highest salary? Massachusetts is the state with the highest annual income of $76,600. This salary is significantly more than the national average salary of $63,795.
1974. Minimum wage: $2 In 2025 money: $13.63 Had the government not increased the minimum wage in 1974, It would have cratered from $13.63 in today's money all the way down to $10.91, which is ...
Donald Trump's administration is moving to exert more control over the federal government's technology, ordering that CIOs should be politically appointed.
C3a may refer to: C3a (complement) C3a receptor; C 3 A, or 3CaO·Al 2 O 3, tricalcium aluminate in cement chemist notation, one of the 4 mineral phases of the ...