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This is a major piece of evidence that statins work in another way than the lowering of cholesterol (called pleiotropic effects). [35] Simvastatin is an effective serum lipid-lowering drug that can decrease low density lipoprotein (LDL) levels by up to 50%. [citation needed] Simvastatin had been shown to interact with lipid-lowering ...
Cholesterol synthesis appears to occur mostly at night, [139] so statins with short half-lives are usually taken at night to maximize their effect. Studies have shown greater LDL and total cholesterol reductions in the short-acting simvastatin taken at night rather than the morning, [ 140 ] [ 141 ] but have shown no difference in the long ...
The Scandinavian Simvastatin Survival Study (also known as the 4S study), was a multicentre, randomized, double-blind, placebo-controlled clinical trial, which provided the initial data that supported the use of the cholesterol-lowering drug, simvastatin, in people with a moderately raised cholesterol and coronary heart disease (CHD); that is people who had previously had a heart attack or angina.
Statins or other medications to treat high cholesterol levels Medications to treat blood clots If your doctor thinks that you’re at a high risk of developing complications, they may recommend ...
Statins “help reduce the risk of plaque ruptures and stabilize the blood vessels” in addition to reducing cholesterol, Serwer says. These medications are a “first-line therapy, after diet ...
Scientists believe statins, cheap cholesterol-lowering medications, could be used for cancer prevention. Statins have anti-inflammatory effects, which could be used to target cancers linked to ...