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Simvastatin, sold under the brand name Zocor among others, is a statin, a type of lipid-lowering medication. [4] It is used along with exercise, diet, and weight loss to decrease elevated lipid levels . [ 4 ]
[17] [18] The medication appears to work equally well regardless of sex, [19] although some sex-related differences in treatment response were described. [20] If there is an underlying history of cardiovascular disease, it has a significant impact on the effects of statin.
So simvastatin is acting in the mouse to block both cholesterol made by the cancer cells themselves and by the liver, and sulfopin is working in the tumor cells to decrease synthesis of cholesterol.
The Scandinavian Simvastatin Survival Study (also known as the 4S study), was a multicentre, randomized, double-blind, placebo-controlled clinical trial, which provided the initial data that supported the use of the cholesterol-lowering drug, simvastatin, in people with a moderately raised cholesterol and coronary heart disease (CHD); that is people who had previously had a heart attack or angina.
That's more people than are eligible to take statins. "These numbers really are staggering," NBC medical contributor Dr. Natalie Azar said on TODAY. "It's studies like this that we hope will ...
“Vitamin D can interact with statins, steroids and thiazide diuretics,” Zumpano says. The time of day matters less than whether you take it with food, which affects the absorption of vitamin D ...
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