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Sergliflozin etabonate discontinued after phase II trials. [ 36 ] Sotagliflozin (Inpefa) is a dual SGLT1/SGLT2 inhibitor approved by the US Food and Drug Administration (FDA) in May 2023, to reduce the risk of cardiovascular death, hospitalization for heart failure, and urgent heart failure visit in adults with heart failure or type 2 diabetes ...
A 2010 phase 2 trial found cetilistat significantly reduced weight and was better tolerated than orlistat. [ 34 ] SGLT2 inhibitors cause the loss of 60–100 grams (2.1–3.5 oz) glucose in the urine each day and are associated with a modest, sustained weight loss of 1.5–2 kilograms (3.3–4.4 lb) in people with type 2 diabetes.
If you’ve ever (over)eaten a big bowl of pasta, only to feel sleepy and lethargic a few minutes later, that’s known as a good old food coma. A blood sugar spike and subsequent crash can do ...
Acarbose [1] [2] is an anti-diabetic drug used to treat diabetes mellitus type 2 and, in some countries, prediabetes. It is a generic sold in Europe and China as Glucobay , in North America as Precose (Bayer Pharmaceuticals), and in Canada as Prandase . Acarbose is a starch blocker.
Dorzolamide is a sulfonamide and topical carbonic anhydrase II inhibitor. It is indicated for the reduction of elevated intraocular pressure in patients with open-angle glaucoma or ocular hypertension and who are insufficiently responsive to beta-blockers. Inhibition of carbonic anhydrase II in the ciliary processes of the eye decreases aqueous ...
Adults with mild type 2 diabetes might improve their insulin sensitivity by following a low-carb diet, thus potentially eliminating the need for medication, a new study suggests.