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His fluid magnesia product was patented two years after his death, in 1873. [15] The term milk of magnesia was first used by Charles Henry Phillips in 1872 for a suspension of magnesium hydroxide formulated at about 8% w/v. [16] It was sold under the brand name Phillips' Milk of Magnesia for medicinal usage.
However it is insoluble in water. Insoluble magnesium salts such as magnesium oxide or magnesium hydroxide (milk of magnesia) depend on stomach acid for neutralization before they can be absorbed, and thus are relatively poor oral magnesium sources, on average. Magnesium sulfate (Epsom salts) is soluble in water.
Phillips produced milk of magnesia and other pharmaceuticals at his Glenbrook firm, which incorporated in 1885 as the Charles H. Phillips Company.After Phillips' death of apoplexy in New York on 29 October 1888, [4] his four sons ran the corporation until 1923, when it was acquired by Sterling Drug, Inc.
The structures of solid magnesium citrates have been characterized by X-ray crystallography.In the 1:1 salt, only one carboxylate of citrate is deprotonated. It has the formula Mg(H 2 C 6 H 5 O 7) 2 The other form of magnesium citrate has the formula Mg(HC 6 H 5 O 7)(H 2 O) 2, consisting of the citrate dianion (both carboxylic acids are deprotonated). [1]
Hypermagnesemia is an electrolyte disorder in which there is a high level of magnesium in the blood. [3] Symptoms include weakness, confusion, decreased breathing rate, and decreased reflexes.
An adult body has 22–26 grams of magnesium, [15] [113] with 60% in the skeleton, 39% intracellular (20% in skeletal muscle), and 1% extracellular. [15] Serum levels are typically 0.7–1.0 mmol/L or 1.8–2.4 mEq /L. Serum magnesium levels may be normal even when intracellular magnesium is deficient.