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Angle-resolved low-coherence interferometry (a/LCI) is an emerging [when?] biomedical imaging technology which uses the properties of scattered light to measure the average size of cell structures, including cell nuclei. The technology shows promise as a clinical tool for in situ detection of dysplastic, or precancerous tissue.
Vertical scanning interferometry is an example of low-coherence interferometry, which exploits the low coherence of white light. Interference will only be achieved when the path length delays of the interferometer are matched within the coherence time of the light source. VSI monitors the fringe contrast rather than the shape of the fringes.
This axial shift will make photons appear like they appear deeper from the sample than they actually are. The presence of multiple scattering events causes a distribution of path lengths that intrinsically blurs the image, resulting in a maximum millimeter-scale resolution which is substantially poorer than OCT which operates at a micrometer ...
Angle-resolved low-coherence interferometry (a/LCI) uses scattered light to measure the sizes of subcellular objects, including cell nuclei. This allows interferometry depth measurements to be combined with density measurements. Various correlations have been found between the state of tissue health and the measurements of subcellular objects.
Another application of the Michelson interferometer is in optical coherence tomography (OCT), a medical imaging technique using low-coherence interferometry to provide tomographic visualization of internal tissue microstructures. As seen in Fig. 8, the core of a typical OCT system is a Michelson interferometer.
Mie theory has been used to determine whether scattered light from tissue corresponds to healthy or cancerous cell nuclei using angle-resolved low-coherence interferometry. Clinical laboratory analysis
Optical coherence tomography (OCT) is an imaging technique that utilizes low-coherence interferometry to generate high-resolution cross-sectional images of biological tissues. [26] It can, thus, provide information about the microstructure and vascular network of the neurovascular unit. [27]
The coherence length determines the width of the correlogram, which relies on the spectral width of the light source, as well as on structural aspects such as the spatial coherence of the light source and the numerical aperture (NA) of the optical system. The following discussion assumes that the dominant contribution to the coherence length is ...