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  2. Epistasis - Wikipedia

    en.wikipedia.org/wiki/Epistasis

    When assaying epistasis within a gene, site-directed mutagenesis can be used to generate the different genes, and their protein products can be assayed (e.g. for stability or catalytic activity). This is sometimes called a double mutant cycle and involves producing and assaying the wild type protein, the two single mutants and the double mutant.

  3. Epistasis and functional genomics - Wikipedia

    en.wikipedia.org/wiki/Epistasis_and_functional...

    Fitness epistasis (an interaction between non-allelic genes) is positive (in other words, diminishing, antagonistic or buffering) when a loss of function mutation of two given genes results in exceeding the fitness predicted from individual effects of deleterious mutations, and it is negative (that is, reinforcing, synergistic or aggravating ...

  4. Genetic architecture - Wikipedia

    en.wikipedia.org/wiki/Genetic_architecture

    At the most basic, individual level, genetic architecture describes the genetic basis for differences between individuals, species, and populations. This can include, among other details, how many genes are involved in a specific phenotype and how gene interactions, such as epistasis, influence that phenotype. [1]

  5. Polymorphism (biology) - Wikipedia

    en.wikipedia.org/wiki/Polymorphism_(biology)

    Epistasis occurs when the expression of one gene is modified by another gene. For example, gene A only shows its effect when allele B1 (at another locus) is present, but not if it is absent. This is one of the ways in which two or more genes may combine to produce a coordinated change in more than one characteristic (for instance, in mimicry).

  6. Functional genomics - Wikipedia

    en.wikipedia.org/wiki/Functional_genomics

    Systematic pairwise deletion of genes or inhibition of gene expression can be used to identify genes with related function, even if they do not interact physically. Epistasis refers to the fact that effects for two different gene knockouts may not be additive; that is, the phenotype that results when two genes are inhibited may be different ...

  7. Genotype - Wikipedia

    en.wikipedia.org/wiki/Genotype

    Epistasis is when the phenotype of one gene is affected by one or more other genes. [21] This is often through some sort of masking effect of one gene on the other. [ 22 ] For example, the "A" gene codes for hair color, a dominant "A" allele codes for brown hair, and a recessive "a" allele codes for blonde hair, but a separate "B" gene controls ...

  8. Famous Streamers: Meet The 20 Twitch Stars Changing The Game

    www.aol.com/lifestyle/famous-streamers-meet-20...

    Auronplay, real-name Raúl Álvarez Genes, is the third-most followed Twitch streamer with 16.7 million followers. ... The matches are 40 minutes long and have different rules, including “power ...

  9. Hypostatic gene - Wikipedia

    en.wikipedia.org/wiki/Hypostatic_gene

    A hypostatic gene is one whose phenotype is altered by the expression of an allele at a separate locus, in an epistasis event. [ 1 ] Example: In labrador retrievers , the chocolate coat colour is a result of homozygosity for a gene that is epistatic to the "black vs. brown" gene.