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Inhibition of adult neurogenesis in the hippocampus has been shown to have various effects on learning and memory, conditioning, and investigative behaviors. Impaired fear conditioning has been seen in studies involving rats with a lack of adult neurogenesis in the hippocampus. [58]
The main function of the SGZ is to carry out hippocampal neurogenesis, the process by which new neurons are bred and functionally integrated into the granular cell layer of the dentate gyrus. Contrary to long-standing beliefs, neurogenesis in the SGZ occurs not only during prenatal development but throughout adult life in most mammals ...
[19] [20] [21] The hippocampus plays a crucial role in the formation of new declarative memories, and it has been theorized that the reason human infants cannot form declarative memories is because they are still undergoing extensive neurogenesis in the hippocampus and their memory-generating circuits are immature. [22]
However, the SVZ of the ventral telencephalon persists throughout life. The adult SVZ is composed of four distinct layers [5] of variable thickness and cell density as well as cellular composition. Along with the dentate gyrus of the hippocampus, the SVZ is one of two places where neurogenesis has been found to occur in the adult mammalian ...
The two areas for which adult neurogenesis is well established are the olfactory bulb, which is involved in the sense of smell, and the dentate gyrus of the hippocampus, where there is evidence that the new neurons play a role in storing newly acquired memories. With these exceptions, however, the set of neurons that is present in early ...
This research revealed some degree of adult neurogenesis in the hippocampus and olfactory bulb of rats, and paved the way for the possibility of neuropoiesis in the adult mammalian brain. Following Altman's work, thymidine-H 3 injections were used to examine the brains of a variety of other species. In the late 1970s Steven Goldman used this ...
The dentate gyrus (DG) is one of the subfields of the hippocampus, in the hippocampal formation.The hippocampal formation is located in the temporal lobe of the brain, and includes the hippocampus (including CA1 to CA4) subfields, and other subfields including the dentate gyrus, subiculum, and presubiculum.
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