Search results
Results From The WOW.Com Content Network
Photolabile protecting groups bear a chromophore, which is activated through radiation with an appropriate wavelength and so can be removed. [6] For examples the o-nitrobenzylgroup ought be listed here. The rare double-layer protecting group is a protected protecting group, which exemplify high stability.
The ease of installation of the protecting group follows the order: 1 o > 2 o > 3 o, allowing the least hindered hydroxyl group to be protected in the presence of more hindered hydroxyls. [ 4 ] Protection of equatorial hydroxyl groups can be achieved over axial hydroxyl groups by the use of a cationic silyl species generated by tert ...
Silyl ethers are a group of chemical compounds which contain a silicon atom covalently bonded to an alkoxy group. The general structure is R 1 R 2 R 3 Si−O−R 4 where R 4 is an alkyl group or an aryl group. Silyl ethers are usually used as protecting groups for alcohols in organic synthesis.
This is useful because alcohols are poor leaving groups in S N 2 reactions, in contrast to the tosylate group. It is the transformation of alkyl alcohols to alkyl tosylates that allows an S N 2 reaction to occur in the presence of a good nucleophile. A tosyl group can function as a protecting group in organic synthesis. Alcohols can be ...
The primary alcohols have general formulas RCH 2 OH; secondary ones are RR'CHOH; and tertiary ones are RR'R"COH, where R, R', and R" stand for alkyl groups. Subcategories This category has the following 3 subcategories, out of 3 total.
The protection mechanism begins with the base deprotonating the alcohol group. Next, the deprotonated alcohol group attacks the silyl atom of the silyl halide compound. The halide acts as a leaving group and ends up in solution. A workup step follows to remove any excess base within the solution. The overall reaction scheme is as follows:
Main page; Contents; Current events; Random article; About Wikipedia; Contact us
The term alcohol originally referred to the primary alcohol ethanol (ethyl alcohol), which is used as a drug and is the main alcohol present in alcoholic drinks. The suffix -ol appears in the International Union of Pure and Applied Chemistry (IUPAC) chemical name of all substances where the hydroxyl group is the functional group with the ...