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A 2002 meta-analysis that included five double-blind trials examining the short-term (2–8 weeks) effects of a yogurt with probiotic strains on serum cholesterol levels found little effect of 8.5 mg/dL (0.22 mmol/L) (4% decrease) in total cholesterol concentration, and a decrease of 7.7 mg/dL (0.2 mmol/L) (5% decrease) in serum LDL concentration.
The definition of prebiotics and the food ingredients that can fall under this classification, has evolved since its first definition in 1995. [3] In its earliest definition, the term prebiotics was used to refer to non-digestible food ingredients that were beneficial to the host through their selective stimulation of specific bacteria within the colon.
Macrobiotics was founded by George Ohsawa and popularized in the United States by his disciple Michio Kushi. [18] In the 1960s, the earliest and most strict variant of the diet was termed the "Zen macrobiotic diet" which claimed to cure cancer, epilepsy, gonorrhea, leprosy, syphilis and many other diseases.