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  2. Missing heritability problem - Wikipedia

    en.wikipedia.org/wiki/Missing_heritability_problem

    The missing heritability problem was named as such in 2008 (after the "missing baryon problem" in physics).The Human Genome Project led to optimistic forecasts that the large genetic contributions to many traits and diseases (which were identified by quantitative genetics and behavioral genetics in particular) would soon be mapped and pinned down to specific genes and their genetic variants by ...

  3. Thrifty gene hypothesis - Wikipedia

    en.wikipedia.org/wiki/Thrifty_gene_hypothesis

    [27] [28] This leaves a large gap between the pregenomic and emerging genomic estimates of heritability of obesity and Type 2 diabetes, sometimes called the "missing heritability problem." The reasons for this discrepancy are not completely understood.

  4. Heritability - Wikipedia

    en.wikipedia.org/wiki/Heritability

    The scarce success of molecular-genetic studies to corroborate such population-genetic studies' conclusions is the missing heritability problem. [35] Eric Turkheimer has argued that newer molecular methods have vindicated the conventional interpretation of twin studies, [ 35 ] although it remains mostly unclear how to explain the relations ...

  5. Genome-wide complex trait analysis - Wikipedia

    en.wikipedia.org/wiki/Genome-wide_complex_trait...

    Estimation in biology/animal breeding using standard ANOVA/REML methods of variance components such as heritability, shared-environment, maternal effects etc. typically requires individuals of known relatedness such as parent/child; this is often unavailable or the pedigree data unreliable, leading to inability to apply the methods or requiring strict laboratory control of all breeding (which ...

  6. Attention deficit hyperactivity disorder controversies

    en.wikipedia.org/wiki/Attention_deficit...

    However, some have questioned whether a genetic connection exists as no single gene has been found – this is known as the missing heritability problem, which ADHD shares with many other heritable human traits such as schizophrenia. [17]

  7. Jon Seger - Wikipedia

    en.wikipedia.org/wiki/Jon_Seger

    In addition, he recently received an NSF grant to continue his work on the so-called "missing heritability" problem. His whale lice work had already shown that a genome should have many weakly deleterious mutations of small effect taken on their own but potentially large effect when taken together.

  8. Tribal leaders cite problems with California's Feather Alert ...

    www.aol.com/news/tribal-leaders-cite-problems...

    Tribal members said these denials are reminiscent of historical traumas linked to decades of under-reported cases of missing and murdered people — the reason the Feather Alert was created in the ...

  9. Gene-centered view of evolution - Wikipedia

    en.wikipedia.org/wiki/Gene-centered_view_of...

    The gene-centered view of evolution, gene's eye view, gene selection theory, or selfish gene theory holds that adaptive evolution occurs through the differential survival of competing genes, increasing the allele frequency of those alleles whose phenotypic trait effects successfully promote their own propagation.