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The effects of trimethoprim causes a backlog of dihydrofolate (DHF) and this backlog can work against the inhibitory effect the drug has on tetrahydrofolate biosynthesis. This is where the sulfamethoxazole comes in; its role is in depleting the excess DHF by preventing it from being synthesised in the first place.
Other studies, however, have found fixed-dose combinations to be useful for this purpose. [2] References This page was last edited on 26 September ...
For dogs, a dose ranges from 2.75 - 5.5 mg/kg once a day. The duration of treatment is usually at least five days, longer if there is a concurrent fungal or yeast infection. [ 4 ] Maximum duration of treatment is 30 days.
Its Tmax (or time to reach maximum drug concentration in plasma) occurs 1 to 4 hours after oral administration. The mean serum half-life of sulfamethoxazole is 10 hours. [8] However, the half-life of the drug noticeably increases in people with creatinine clearance rates equal to or less than 30 mL/minute.
Dogs receiving 10 times the labeled dosage rate of enrofloxacin for at least 14 days developed only vomiting and anorexia. Death did occur in some dogs when fed 25 times the labeled rate for 11 days, however. Oral LD 50: greater than 5000 mg/kg; Dermal LD 50: greater than 2000 mg/kg; Inhalation LD 50: greater than 3547 mg/m3 (4-hour exposure)
An equianalgesic chart is a conversion chart that lists equivalent doses of analgesics (drugs used to relieve pain). Equianalgesic charts are used for calculation of an equivalent dose (a dose which would offer an equal amount of analgesia) between different analgesics. [1]
Drug fever; Periarteritis nodosa; Hepatic necrosis; Pancreatitis; Myelosuppression; Haemolysis [a] Stevens–Johnson syndrome [b] Drug reaction with eosinophilia and systemic symptoms; Toxic epidermal necrolysis [c] Ataxia [d] Clostridioides difficile colitis; Aseptic meningitis [e] Pseudomembranous colitis; Interstitial nephritis; Fulminant ...
The following is a list of antibiotics.The highest division between antibiotics is bactericidal and bacteriostatic.Bactericidals kill bacteria directly, whereas bacteriostatics prevent them from dividing.