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  2. Skin secretions - Wikipedia

    en.wikipedia.org/wiki/Skin_secretions

    Some skin secretions are associated with body hair. Skin secretions originate from glands that in dermal layer of the epidermis. Sweat, a physiological aid to body temperature regulation, is secreted by eccrine glands. Sebaceous glands secrete the skin lubricant sebum. Sebum is secreted onto the hair shaft and it prevents the hair from splitting.

  3. Keratinocyte - Wikipedia

    en.wikipedia.org/wiki/Keratinocyte

    Keratinocytes form tight junctions with the nerves of the skin and hold the Langerhans cells and intra-dermal lymphocytes in position within the epidermis. Keratinocytes also modulate the immune system : apart from the above-mentioned antimicrobial peptides and chemokines they are also potent producers of anti-inflammatory mediators such as IL ...

  4. Epidermis - Wikipedia

    en.wikipedia.org/wiki/Epidermis

    The epidermis is the outermost of the three layers that comprise the skin, the inner layers being the dermis and hypodermis. [1] The epidermal layer provides a barrier to infection from environmental pathogens [2] and regulates the amount of water released from the body into the atmosphere through transepidermal water loss.

  5. Human skin - Wikipedia

    en.wikipedia.org/wiki/Human_skin

    The human skin is the outer covering of the body and is the largest organ of the integumentary system. The skin has up to seven layers of ectodermal tissue guarding muscles, bones, ligaments and internal organs. Human skin is similar to most of the other mammals' skin, and it is very similar to pig skin.

  6. Stratum corneum - Wikipedia

    en.wikipedia.org/wiki/Stratum_corneum

    This complex surrounds cells in the stratum corneum and contributes to the skin's barrier function. Corneodesmosomes (modified desmosomes) facilitate cellular adhesion by linking adjacent cells within this epidermal layer. These complexes are degraded by proteases, eventually permitting cells to be shed at the surface. Desquamation and ...

  7. Corneocyte - Wikipedia

    en.wikipedia.org/wiki/Corneocyte

    Corneocytes are terminally differentiated keratinocytes and compose most of the stratum corneum, the outermost layer of the epidermis. They are regularly replaced through desquamation and renewal from lower epidermal layers and are essential for its function as a skin barrier.

  8. Skin repair - Wikipedia

    en.wikipedia.org/wiki/Skin_repair

    Damaged sweat and sebaceous glands, hair follicles, muscle cells, and nerves are seldom repaired. They are usually replaced by the fibrous tissue. The result is the formation of an inflexible, fibrous scar tissue. Human skin cells are capable of repairing UV-induced DNA damages by the process of nucleotide excision repair. [2]

  9. Involucrin - Wikipedia

    en.wikipedia.org/wiki/Involucrin

    Involucrin is a highly reactive, soluble, transglutaminase substrate protein present in keratinocytes of epidermis and other stratified squamous epithelia. [7] [8] It first appears in the cell cytosol, but ultimately becomes cross-linked to membrane proteins by transglutaminase thus helping in the formation of an insoluble envelope beneath the plasma membrane functioning as a glutamyl donor ...