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Aspirin-exacerbated respiratory disease (AERD), also called NSAID-exacerbated respiratory disease (N-ERD) or historically aspirin-induced asthma and Samter's Triad, is a long-term disease defined by three simultaneous symptoms: asthma, chronic rhinosinusitis with nasal polyps, and intolerance of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs).
Asthma phenotyping and endotyping has emerged as a novel approach to asthma classification inspired by precision medicine which separates the clinical presentations of asthma, or asthma phenotypes, from their underlying causes, or asthma endotypes. The best-supported endotypic distinction is the type 2-high/type 2-low distinction.
Excluding ACO with late-onset asthma, ACO has better survival (lower mortality) than COPD, but higher mortality compared to asthma. [4] In other studies, ACO was associated with worse dyspnea symptoms, more coughing, wheezing , and sputum production, as well as more frequent and more severe exacerbations as compared to COPD or asthma.
Doctors warn that if symptoms go undetected and untreated, the condition could cause a loss of lung function. But once diagnosed, adult asthma can be treated with prescription medication, allowing ...
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However, late-onset asthma may frequently be allergic. Many patients still have elevated IgE levels, [ 7 ] may test positive against a broader panel of known allergens than is normally tested for in specific IgE testing and prick tests , [ 8 ] and frequently have comorbid allergic rhinitis and atopic dermatitis .