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Based on positive clinical results of regeneration in periodontology research in the 1980s, research began to focus on the potential for re-building alveolar bone defects using guided bone regeneration. The theory of Guided tissue regeneration has been challenged in dentistry. The GBR principle was first examined by Dahlin et al. in 1988 on rats.
It is still unclear exactly how EMD participates in the regeneration process. [5] But it has been demonstrated that EMD serves to promote periodontal ligament fibroblast proliferation and growth and inhibit epithelial cell proliferation and growth; [3] this is a key feature in EMD-promoted periodontal tissue regeneration, because the faster-growing epithelium will ordinarily compete very ...
The first membranes developed were nonresorbable and required a second surgery for membrane removal some weeks later. The need for a second surgical procedure hindered the utilization of the original barrier membranes, which led to the development of resorbable membranes; [1] research indicates no statistically significant difference in surgical success between the two types.
Guided bone reconstruction is a technique in which bone growth is enhanced by preventing soft tissue ingrowth into the desired area and utilizes either resorbable or nonresorbable membranes. [22] Both metallic membranes [ 23 ] and membranes supported by a titanium frame [ 24 ] [ 25 ] [ 26 ] have been tested and have been successful.
Socket preservation or alveolar ridge preservation is a procedure to reduce bone loss after tooth extraction. [1] [2] After tooth extraction, the jaw bone has a natural tendency to become narrow, and lose its original shape because the bone quickly resorbs, resulting in 30–60% loss in bone volume in the first six months. [3]
A successful tissue regeneration relies on an appropriate source of stem progenitor cells, growth factors and scaffolds to control the development of the specific tissue. [19] The first component for tissue engineering is an appropriate source of progenitor/stem cells by using cells which are able to differentiate into the desired tissue component.
These agents not only help improve wound healing but also stimulate regeneration of the lost bone, periodontal ligament and cementum restoring the complete periodontal attachment apparatus. Currently Emdogain is the only approved host modulatory agent of this type. [4] Growth Factors; Bone Morphogenic Proteins
This article follows the 1999 classification, although the ICD-10 (10th revision of the International Statistical Classification of Diseases and Related Health Problems) differs significantly. The latest World Workshop on the Classification of Periodontal and Peri-Implant Diseases and Conditions was held in 2017. this updated classification ...