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In contrast, a permanent loss of smell may be caused by death of olfactory receptor neurons in the nose or by brain injury in which there is damage to the olfactory nerve or damage to brain areas that process smell (see olfactory system). The lack of the sense of smell at birth, usually due to genetic factors, is referred to as congenital anosmia.
The olfactory nerve, also known as the first cranial nerve, cranial nerve I, or simply CN I, is a cranial nerve that contains sensory nerve fibers relating to the sense of smell. The afferent nerve fibers of the olfactory receptor neurons transmit nerve impulses about odors to the central nervous system ( olfaction ).
Anosmia is the inability to perceive odor, or in other words a lack of functioning olfaction.Many patients may experience unilateral or bilateral anosmia. A temporary loss of smell can be caused by a blocked nose or infection. In contrast, a permanent loss of smell may be caused by death of olfactory receptor neurons in the nose or by brain injury in which there is damage to the
Currently, there is no definitive treatment for congenital anosmia, as the condition involves the absence or underdevelopment of the olfactory bulbs and tracts, which are critical for the sense of smell. Management primarily focuses on safety precautions and coping strategies to mitigate the risks associated with the inability to smell. [2] [4] [5]
The peripheral olfactory system consists mainly of the nostrils, ethmoid bone, nasal cavity, and the olfactory epithelium (layers of thin tissue covered in mucus that line the nasal cavity). The primary components of the layers of epithelial tissue are the mucous membranes, olfactory glands, olfactory neurons, and nerve fibers of the olfactory ...
Connecting the olfactory bulb and the nasal cavity is the olfactory nerve. Some researchers worry the olfactory pathway may also be an entry point for microplastics getting into the brain, beyond ...
Specifically, the olfactory nerve and bulbs become necrotic and hemorrhagic. [19] Spinal flexion leads to nuchal rigidity , or stiff neck, due to the stretching of the inflamed meninges. [ 16 ] The increase in intracranial pressure stimulates the area postrema to create nausea sensations which may lead to brain herniation and damage to the ...
The nerve cells of the olfactory epithelium project into the olfactory bulb of the brain, which provides a direct connection between the brain and the external environment. The transfer of drugs to the brain from the blood circulation is normally hindered by the blood–brain barrier (BBB), which is virtually impermeable to passive diffusion of ...