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Alcoholic polyneuropathy is not life-threatening but may significantly affect one's quality of life. Effects of the disease range from mild discomfort to severe disability. [5] It is difficult to assess the prognosis of a patient because alcohol dependence results in difficulty maintaining abstinence from drinking alcohol. It has been shown ...
The normal presence of these channels [10] in axons of both the central nervous system [11] and peripheral nervous system accounts for the symptoms and signs arising from brain [12] and nerves. [13] The disease has been modelled in transgenic mice. [14] Dogs show a different phenotype from humans, with predominantly spinocerebellar ataxia. [15]
[3] [42] A very high percentage of patients with Wernicke–Korsakoff syndrome also have peripheral neuropathy, and many people who consume excess alcohol have this neuropathy without other neurologic signs or symptoms. [43] Korsakoff's occurs much more frequently in WE due to chronic alcoholism. [42]
Patients with hereditary motor and sensory neuropathies are diagnosed through a physical evaluation that looks for muscle atrophy, weakness, and sensory responses. [3] In addition to this, electromyography and motor nerve conduction tests can help clinicians decide what type of motor and sensory neuropathy it is and how severe the disease is.
Sural nerve biopsy; biopsy is considered for those patients in whom the diagnosis is not completely clear, when other causes of neuropathy (e.g., hereditary, vasculitic) cannot be excluded, or when profound axonal involvement is observed on EMG. Ultrasound of the peripheral nerves may show swelling of the affected nerves. [32] [33] [34]
Behr syndrome is characterized by the association of early-onset optic atrophy with spinocerebellar degeneration resulting in ataxia, pyramidal signs, peripheral neuropathy and developmental delay. [1] [2] Although it is an autosomal recessive disorder, heterozygotes may still manifest much attenuated symptoms. [3]
Neurological symptoms may include diffuse leukoencephalopathy, peripheral neuropathy, and myopathy. [2] Ocular symptoms may include retinal degeneration, ophthalmoplegia, and ptosis. [2] [5] Those with MNGIE are often thin and experience continuous weight loss. The characteristic thinness of MNGIE patients is caused by multiple factors ...
In many cases, symptoms are mild enough to go unnoticed. The time period between episodes is known to vary between individuals. HNPP has not been found to alter the lifespan, although in some cases a decline in quality of life is noticed. Some sufferers (10–15%) report various pains growing in severity with progression of the disease. [1]