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Hydrogen therapy is the use of molecular hydrogen (H 2) for therapeutic purposes. H 2 has therapeutic benefits due to its antioxidant and anti-inflammatory effects, as well as due to its role as an inducer of gene expression, [1] H 2 is not cytotoxic or explosive below 4% concentration. [2]
Such reactions (summarized in formula below) involve the removal of two hydrogen atoms from the reactant (R), in the form of a hydride ion (H −), and a proton (H +). The proton is released into solution, while the reductant RH 2 is oxidized and NAD + reduced to NADH by transfer of the hydride to the nicotinamide ring. RH 2 + NAD + → NADH ...
Molecular oxygen (O 2) participates directly or indirectly in this reaction pathway forming the radical anion known as superoxide (O 2 •–). The superoxide radical can be further reduced to form hydrogen peroxide (H 2 O 2), which can also be reduced to form highly reactive free hydroxyl radicals (HO •) via Fenton-like reactions.
Hydrogen is a chemical element; it has symbol H and atomic number 1. It is the lightest element and, at standard conditions, is a gas of diatomic molecules with the formula H 2, sometimes called dihydrogen, [11] hydrogen gas, molecular hydrogen, or simply hydrogen. It is colorless, odorless, [12] non-toxic, and highly combustible.
As a form of molecular medicine, targeted therapy blocks the growth of cancer cells by interfering with specific targeted molecules needed for carcinogenesis and tumor growth, [2] rather than by simply interfering with all rapidly dividing cells (e.g. with traditional chemotherapy).
On the basis of this property, supramolecular polymers are capable of being a drug carrier. Making use of hydrogen bonding between nucleobases to induce self-assemble into pH-sensitive spherical micelles. Gene transfection: Effective and low-toxic nonviral cationic vectors are highly desired in the field of gene therapy. [50]