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Calcitonin was extracted from the ultimobranchial glands (thyroid-like glands) of fish, particularly salmon. Salmon calcitonin resembles human calcitonin, but is more active. At present, it is produced either by recombinant DNA technology or by chemical peptide synthesis. The pharmacological properties of the synthetic and recombinant peptides ...
Parafollicular cells secrete calcitonin, a hormone that participates in the regulation of calcium metabolism. Calcitonin lowers blood levels of calcium by inhibiting the resorption of bone by osteoclasts , and its secretion is increased proportionally with the concentration of calcium.
Calcitonin gene-related peptide (CGRP) is a member of the calcitonin family of peptides consisting of calcitonin, amylin, adrenomedullin, adrenomedullin 2 and calcitonin‑receptor‑stimulating peptide. Calcitonin is mainly produced by thyroid C cells whilst CGRP is secreted and stored in the nervous system. [1]
PTH is secreted when [Ca 2+] is decreased (calcitonin is secreted when serum calcium levels are elevated). The G-protein-coupled calcium receptors bind extracellular calcium and may be found on the surface on a wide variety of cells distributed in the brain , heart , skin , stomach , C cells, and other tissues.
The thyroid gland secretes three hormones: the two thyroid hormones – triiodothyronine (T 3) and thyroxine (T 4) – and a peptide hormone, calcitonin. The thyroid hormones influence the metabolic rate and protein synthesis and growth and development in children. Calcitonin plays a role in calcium homeostasis. [1]
The parathyroid glands, of which there are 4–6, are found on the back of the thyroid glands, and secrete parathyroid hormone, [2] This causes an increase in blood calcium levels by targeting bone, the intestine, and the kidneys. The parathyroid hormone is the antagonist of calcitonin. Parathyroid hormone release is triggered by falling blood ...
Involved in orgasm, trust between people, [2] and circadian homeostasis (body temperature, activity level, wakefulness). [3] 50 Pancreatic polypeptide: Peptide: Pancreas: PP cells: pancreatic polypeptide receptor 1: Self-regulation of pancreatic secretions (endocrine and exocrine). It also affects hepatic glycogen levels and gastrointestinal ...
Calcitonin-producing parafollicular cells are also found along the basement membrane of the thyroid follicle, interspersed between follicular cells; and in spaces between the spherical follicles. Parafollicular cells can be distinguished from follicular cells based on their lighter staining cytoplasm using H&E .