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Pyoderma gangrenosum is a rare, inflammatory skin disease where painful pustules or nodules become ulcers that progressively grow. [3] Pyoderma gangrenosum is not infectious. [3] Treatments may include corticosteroids, ciclosporin, infliximab, or canakinumab. [2] The disease was identified in 1930.
The inflammation and ulceration that occurs as a result of pathergy in pyoderma gangrenosum often responds to systemic steroid therapy. The pathergy reaction is a unique feature of Behçet's disease and, according to the International Study Group for Behcet's Disease, is among the major criteria required for the diagnosis.
Pyoderma gangrenosum is variably expressed, which means that it is not always present in all individuals with the disease. It presents as poorly healing ulcers with undermined edges. Pathergy is an important feature (this term refers to the tendency of ulcers to arise at points of injury).
Comorbid ailments that may contribute to the formation of chronic wounds include vasculitis (an inflammation of blood vessels), immune suppression, pyoderma gangrenosum, and diseases that cause ischemia. [2] Immune suppression can be caused by illnesses or medical drugs used over a long period, like steroids. [2]
In superficial granulomatous pyoderma, ulcers typically have a clean base and vegetating borders, making them more superficial. Unlike pyoderma gangrenosum, superficial granulomatous pyoderma is more frequently associated with truncal involvement and is not always linked to underlying systemic disease. [2]
Ecthyma gangrenosum is a type of skin lesion characterized by vesicles or blisters, which rapidly evolve into pustules and necrotic ulcers with undermined tender erythematous border. " Ecthyma " means a pus-forming infection of the skin with an ulcer, "gangrenosum" refers to the accompanying gangrene or necrosis.
Pyoderma gangrenosum is a less common skin problem, occurring in under 2%, [69] and is typically a painful ulcerating nodule. [ 68 ] [ 51 ] Clubbing , a deformity of the ends of the fingers, may also be a result of Crohn's disease.
Pyoderma means any skin disease that is pyogenic (has pus). These include superficial bacterial infections such as impetigo , impetigo contagiosa , ecthyma , folliculitis , Bockhart's impetigo , furuncle , carbuncle , tropical ulcer , etc. [ 1 ] [ 2 ] Autoimmune conditions include pyoderma gangrenosum .