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This damage can cause neuronal apoptosis, programmed cell death, which leads to neuropathy. Additionally, functional neuronal deficits have been identified, independent of structural damage, e.g. ion channelopathy, impaired spike encoding in the central [5] and peripheral nervous system.
The mechanism by which RA causes this increased risk remains unknown; the presence of chronic inflammation has been proposed as a contributing factor. [207] It is possible that the use of new biologic drug therapies extend the lifespan of people with RA and reduce the risk and progression of atherosclerosis. [ 208 ]
A Cochrane Review concluded that although metoprolol reduces the risk of atrial fibrillation recurrence, it is unclear whether the long-term benefits outweigh the risks. [33] This medicine may cause changes in blood sugar levels or cover up signs of low blood sugar, such as a rapid pulse rate. [32]
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Arthralgia (from Greek arthro- ' joint ' and -algos ' pain ') literally means 'joint pain'. [ 1 ] [ 2 ] Specifically, arthralgia is a symptom of injury , infection , illness (in particular arthritis ), or an allergic reaction to medication .
A wide range of symptoms can indicate if a person has polymyalgia rheumatica. The classic symptoms include: [2] [11] Pain and stiffness (moderate to severe) in the neck, shoulders, upper arms, thighs, and hips, which inhibits activity, especially in the morning, but which usually persists to some degree throughout the day.
Medication-induced osteonecrosis of the jaw (MIONJ), Bisphosphonate-related osteonecrosis of the jaw (BRONJ) (formerly) Specialty: Oral and maxillofacial surgery: Symptoms: Exposed bone after extraction, pain: Complications: Osteomyelitis of the jaw: Usual onset: After dental extractions: Duration: Variable: Types: Stage 1-Stage 3: Causes
Examples are deep vein thrombosis and pulmonary embolism, the risk of which can be mitigated by certain interventions, such as the administration of anticoagulants (e.g., warfarin or low molecular weight heparins), antiplatelet drugs (e.g., aspirin), compression stockings, and cyclical pneumatic calf compression in high risk patients. [citation ...