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GMP synthase is the second step in the generation of GMP from IMP; the first step occurs when IMP dehydrogenase generates XMP, and then GMP synthetase is able to react with glutamine and ATP to generate GMP. IMP may also be generated into AMP by adenylosuccinate synthetase and then adenylosuccinate lyase. [7]
The enzyme is an allosteric enzyme, so it can be converted from IMP, GMP and AMP in high concentration binds the enzyme to exerts inhibition while PRPP is in large amount binds to the enzyme which causes activation. So IMP, GMP and AMP are inhibitors while PRPP is an activator.
Inosinic acid or inosine monophosphate (IMP) is a nucleotide (that is, a nucleoside monophosphate). ... While AMP synthesis requires GTP, GMP synthesis uses ATP. That ...
The cycle comprises three enzyme-catalysed reactions. The first stage is the deamination of the purine nucleotide adenosine monophosphate (AMP) to form inosine monophosphate (IMP), catalysed by the enzyme AMP deaminase:
The gua operon is responsible for regulating the synthesis of guanosine mono phosphate (GMP), a purine nucleotide, from inosine monophosphate (IMP or inosinate). It consists of two structural genes guaB (encodes for IMP dehydrogenase or and guaA (encodes for GMP synthetase) apart from the promoter and operator region.
Guanosine monophosphate (GMP), also known as 5′-guanidylic acid or guanylic acid (conjugate base guanylate), is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid with the nucleoside guanosine. GMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase guanine; hence it is a ribonucleotide ...
GMP reductase EC 1.7.1.7 (Guanosine 5'-monophosphate oxidoreductase) is an enzyme that catalyzes the irreversible and NADPH-dependent reductive deamination of GMP into IMP. [ 1 ] NADPH + guanosine 5-phosphate = NADP + + inosine 5-phosphate + NH 3
Xanthosine monophosphate (xanthylate) is an intermediate in purine metabolism. [1] It is a ribonucleoside monophosphate.It is formed from IMP via the action of IMP dehydrogenase, and it forms GMP via the action of GMP synthase.