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GMP synthase is the second step in the generation of GMP from IMP; the first step occurs when IMP dehydrogenase generates XMP, and then GMP synthetase is able to react with glutamine and ATP to generate GMP. IMP may also be generated into AMP by adenylosuccinate synthetase and then adenylosuccinate lyase.
This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds carbon-nitrogen ligases with glutamine as amido-N-donor. The systematic name of this enzyme class is glutamyl-tRNA Gln:L-glutamine amido-ligase (ADP-forming). This enzyme participates in glutamate metabolism and alanine and aspartate metabolism.
Glutamine synthetase (GS) (EC 6.3.1.2) [3] is an enzyme that plays an essential role in the metabolism of nitrogen by catalyzing the condensation of glutamate and ammonia to form glutamine: Glutamate + ATP + NH 3 → Glutamine + ADP + phosphate
Carbamoyl phosphate synthetase (glutamine-hydrolysing) (EC 6.3.5.5) is an enzyme that catalyzes the reactions that produce carbamoyl phosphate in the cytosol (as opposed to type I, which functions in the mitochondria).
In enzymology, a NAD + synthase (glutamine-hydrolysing) (EC 6.3.5.1) is an enzyme that catalyzes the chemical reaction. ATP + deamido-NAD + + L-glutamine + H 2 O AMP + diphosphate + NAD + + L-glutamate. In eukaryotes, this enzyme contains a glutaminase domain related to nitrilase. [1]
Also, plasma glutamine (released from the kidneys) requires active transport into the muscle cell (consuming ATP). [11] Consequently, during exercise when the ATP reservoir is low (ADP>ATP), glutamate is produced from branch-chained amino acids (BCAAs) and α-ketoglutarate, as well as from alanine and α-ketoglutarate. [ 12 ]
Guanosine monophosphate (GMP), also known as 5′-guanidylic acid or guanylic acid (conjugate base guanylate), is a nucleotide that is used as a monomer in RNA. It is an ester of phosphoric acid with the nucleoside guanosine. GMP consists of the phosphate group, the pentose sugar ribose, and the nucleobase guanine; hence it is a ribonucleotide ...
76563 Ensembl ENSG00000130348 ENSMUSG00000019863 UniProt Q9H0R6 Q9CZN8 RefSeq (mRNA) NM_018292 NM_001081054 RefSeq (protein) NP_060762 NP_001074523 Location (UCSC) Chr 6: 106.63 – 106.67 Mb Chr 10: 43.75 – 43.78 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Glutaminyl-tRNA synthase (glutamine-hydrolyzing)-like 1 is a protein that in humans is encoded by the QRSL1 gene ...