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Total triiodothyronine (Total T 3) is rarely measured, having been largely superseded by free T3 tests. Total T3 is generally elevated in hyperthyroidism and decreased in hypothyroidism. [2] Reference ranges depend on the method of analysis. Results should always be interpreted using the range from the laboratory that performed the test.
T 3 is the more metabolically active hormone produced from T 4.T 4 is deiodinated by three deiodinase enzymes to produce the more-active triiodothyronine: . Type I present in liver, kidney, thyroid, and (to a lesser extent) pituitary; it accounts for 80% of the deiodination of T 4.
Onset is commonly between 20 and 50 years of age ... than normal levels of radioiodine. Normal ranges for RAI uptake are from 10 to 30%. ... T4 to the more active T3 ...
These normal hormonal changes often make pregnancy look like a hyperthyroid state but may be within the normal range for pregnancy, so it necessary to use trimester specific ranges for TSH and free T4. [23] [24] True hyperthyroidism in pregnancy is most often caused by an autoimmune mechanism from Graves' Disease. [23]
Also in normal pregnancies, adequate levels of maternal thyroid hormone are vital in order to ensure thyroid hormone availability for the foetus and its developing brain. [88] Congenital hypothyroidism occurs in every 1 in 1600–3400 newborns with most being born asymptomatic and developing related symptoms weeks after birth.
Levothyroxine, a drug used to treat hypothyroidism, can lead to reduced bone mass and density in older adults with normal thyroid levels, a small cohort study has shown.