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Injector pens remove some of the complications of syringes by allowing the pen to be "pushed" against the skin at a 90-degree angle (removing the need to inject at a proper angle as is the case with syringes), as well as by replacing a long, thin plunger of a syringe with a simple button which is depressed and held to inject the dose.
By 2008, all-plastic needles were in production and in limited use. One version was made of Vectra (plastic) aromatic liquid crystal polymer tapered from 1.2 mm at the hub to 0.72 mm at the tip (equivalent to 22 gauge metal needle), with an ID/OD ratio of 70%. [16]
The dilution of insulin is such that 1 mL of insulin fluid has 100 standard "units" of insulin. [6] A typical insulin vial may contain 10 mL, for 1000 units. Insulin syringes are made specifically for a patient to inject themselves, and have features to assist this purpose when compared to a syringe for use by a healthcare professional:
The unit of insulin was set by the insulin committee at the University of Toronto. [53] The unit evolved eventually to the old USP insulin unit, where one unit (U) of insulin was set equal to the amount of insulin required to reduce the concentration of blood glucose in a fasting rabbit to 45 m g/d L (2.5 m mol/L). Once the chemical structure ...
The term "high dead space" refers to the fluid remaining within the needle and between the syringe hub and the plunger. This space can be as high as 84 micro liters in conventional syringes. [2] Conventional high dead space syringes have existed since the mass production of plastic syringes with removable needles in 1961. [3]