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You might experience common side effects. There are common side effects associated with most medications, including alprazolam. Some adverse effects to be aware of are: Alternatives to Xanax for Sleep
Trazodone also has sedating effects. [24] Trazodone was approved for medical use in the United States in 1981. [20] It is available as a generic medication. [20] In 2022, it was the eighteenth most commonly prescribed medication in the United States, with more than 27 million prescriptions. [25] [26]
Alprazolam is primarily metabolized via CYP3A4. [52] Combining CYP3A4 inhibitors such as cimetidine, erythromycin, norfluoxetine, fluvoxamine, itraconazole, ketoconazole, nefazodone, propoxyphene, and ritonavir delay the hepatic clearance of alprazolam, which may result in its accumulation [53] and increased severity of its side effects. [54] [55]
The most common side-effects of benzodiazepines are related to their sedating and muscle-relaxing action. They include drowsiness , dizziness, and decreased alertness and concentration. Lack of coordination may result in falls and injuries particularly in the elderly.
A study into the effects of the benzodiazepine receptor antagonist, flumazenil, on benzodiazepine withdrawal symptoms persisting after withdrawal was carried out by Lader and Morton. Study subjects had been benzodiazepine-free for between one month and five years, but all reported persisting withdrawal effects to varying degrees.
Side effects can differ within the drug class due to differences in metabolism and pharmacology. For example, long-acting benzodiazepines have problems of drug accumulation especially in the elderly or those with liver disease, and shorter-acting benzodiazepines have a higher risk of more severe withdrawal symptoms.
This is a list of adverse effects of the antidepressant trazodone, sorted by frequency of occurrence. [1] [2] [3] Very common.
An Australian study (2004) of overdose admissions between 1987 and 2002 found alprazolam, which happens to be the most prescribed benzodiazepine in Australia and the United States, to be more toxic than diazepam and the other three benzodiazepines which it was compared to (alprazolam, diazepam, oxazepam, chlordiazepoxide, and clonazepam).