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The most common reason for high serum FSH concentration is in a female who is undergoing or has recently undergone menopause. High levels of FSH indicate that the normal restricting feedback from the gonad is absent, leading to an unrestricted pituitary FSH production. FSH may contribute to postmenopausal osteoporosis and cardiovascular disease ...
Typical serum FSH levels in POI patients is in the post-menopausal range. [2] Treatment will vary depending on the symptoms. It can include hormone replacement therapy, fertility management, and psychosocial support, as well as annual screenings of thyroid and adrenal function.
They found that 17beta-estradiol and progesterone levels dropped post-menopause while follicle-stimulated hormone (FSH) increased. Researchers also observed that the menopausal mice gained weight.
Testing serum LH and FSH levels are often used to assess hypogonadism in women, particularly when menopause is believed to be happening. These levels change during a woman's normal menstrual cycle, so the history of having ceased menstruation coupled with high levels aids the diagnosis of being menopausal.
Hypoestrogenism is typically found in menopause and aids in diagnosis of other conditions such as POI and functional amenorrhea. [17] [24] Estrogen levels can be tested through several laboratory tests: vaginal maturation index, [clarification needed] progestogen challenge test, and vaginal swabs for small parabasal cells. [19]
Menopause, also known as the climacteric, is the time when menstrual periods permanently stop, marking the end of reproduction. [1] [6] [7] It typically occurs between the ages of 45 and 55, although the exact timing can vary. [8] Menopause is usually a natural change related to a decrease in circulating blood estrogen levels. [3]