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HER2 is the target of the monoclonal antibody trastuzumab (marketed as Herceptin). Trastuzumab is effective only in cancers where HER2 is over-expressed. One year of trastuzumab therapy is recommended for all patients with HER2-positive breast cancer who are also receiving chemotherapy. [33] Twelve months of trastuzumab therapy is optimal.
In 1986 Axel Ullrich, a German scientist working at Genentech, first discovered the Her-2 protein and gave a conference about it in which Slamon was present.Afterwards Slamon proposed to work together, since he suspected that a mutation in Her-2 might cause cancer, eventually they found a kind of aggressive breast cancer with a mutation in the gene responsible for the Her-2 protein and started ...
The film follows the true story of Dr. Dennis Slamon (played by Harry Connick Jr.), who helped develop the breast cancer drug Herceptin, over the course of 8 years from 1988 to 1996. Dr. Dr. Slamon is a physician scientist at UCLA Medical Center ( Los Angeles ), where he has developed the experimental drug Herceptin, which he believes will ...
Trastuzumab, sold under the brand name Herceptin among others, is a monoclonal antibody used to treat breast cancer and stomach cancer. [31] [28] [32] [33] It is specifically used for cancer that is HER2 receptor positive. [31]
Year of discovery Name of the drug Year when the synthesis mechanism was developed Year that was Patented Governmental approval Patented expired 1901: Adrenaline: Jōkichi Takamine, 1901: 1901: 1901: N/A (Natural Hormone) 1906: Oxytocin: Discovered by Henry Hallett Dale, synthesized by Vincent du Vigneaud in 1952: 1925: 1926: N/A (Natural ...
Six months later, Caylee’s remains were found in a wooded area near the Anthony family home. Her cause of death could not be determined, but Casey was charged with first-degree murder. Caylee ...
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