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The binding of alprazolam to the GABA A receptor, a chloride ion channel, enhances the effects of GABA, a neurotransmitter. When GABA binds the GABA A receptor the channel opens and chloride enters the cell which makes it more resistant to depolarisation. Therefore, alprazolam has a depressant effect on synaptic transmission to reduce anxiety.
GABA receptor antagonists are drugs that inhibit the action of GABA. In general these drugs produce stimulant and convulsant effects, and are mainly used for counteracting overdoses of sedative drugs. Examples include bicuculline, securinine and metrazol, and the benzodiazepine GABA A receptor antagonist flumazenil.
A GABA reuptake inhibitor (GRI) is a type of drug which acts as a reuptake inhibitor for the neurotransmitter gamma-Aminobutyric acid (GABA) by blocking the action of the gamma-Aminobutyric acid transporters (GATs). This in turn leads to increased extracellular concentrations of GABA and therefore an increase in GABAergic neurotransmission. [1]
The Mayo Clinic Handbook for Happiness. Da Capo Lifelong Books. ISBN 978-0738217857. Sood, Amit (2013). The Mayo Clinic Guide to Stress-Free Living. Da Capo Lifelong Books. ISBN 978-0738217123. Sood, Amit (2015). Immerse: A 52-Week Course in Resilient Living: A Commitment to Live With Intentionality, Deeper Presence, Contentment, and Kindness.
Gamma-aminobutyric acid, a GABA-B receptor agonist. A GABA receptor agonist is a drug that is an agonist for one or more of the GABA receptors, producing typically sedative effects, and may also cause other effects such as anxiolytic, anticonvulsant, and muscle relaxant effects. [1] There are three receptors of the gamma-aminobutyric acid. The ...
Magnesium also plays a role in muscle relaxation and nerve function. ... this mineral helps the body maintain levels of GABA (or gamma-aminobutyric acid), a neurotransmitter that is responsible ...