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The nucleophilic lysine residue is commonly targeted site in protein bioconjugation, typically through amine-reactive N-hydroxysuccinimidyl (NHS) esters. [3] To obtain optimal number of deprotonated lysine residues, the pH of the aqueous solution must be below the pKa of the lysine ammonium group, which is around 10.5, so the typical pH of the reaction is about 8 and 9.
[8] [9] [10] In modern chemistry, the p stands for "the negative decimal logarithm of", and is used in the term pK a for acid dissociation constants, [11] so pH is "the negative decimal logarithm of H + ion concentration", while pOH is "the negative decimal logarithm of OH- ion concentration".
The iPad (9th generation) [3] [4] (also referred to as the iPad 10.2-inch) is a tablet computer developed and marketed by Apple as the successor to the eighth-generation iPad. It was announced on September 14, 2021, and released on September 24.
A 1990s jukebox musical by Kumble, Rosin, and Ross, was first staged in 2015. After two runs in Los Angeles and a pop-up engagement in New York, Cruel Intentions: The '90s Musical made its Off-Broadway debut at the Greenwich Village nightclub Le Poisson Rouge in November 2017 and ran through April 2018.
First x86 chip to handle 32-bit data sets Reworked and expanded memory protection support including paged virtual memory and virtual-86 mode, features required at the time by Xenix and Unix . This memory capability spurred the development and availability of OS/2 and is a fundamental requirement for modern operating systems like Linux , Windows ...
According to Mikhail B. Sevryuk, in the January 2006 issue of the Bulletin of the American Mathematical Society, "The number of papers and books included in the Mathematical Reviews (MR) database since 1940 (the first year of operation of MR) is now more than 1.9 million, and more than 75 thousand items are added to the database each year. The ...
The seventh member of group 18 is oganesson, an unstable synthetic element whose chemistry is still uncertain because only five very short-lived atoms (t 1/2 = 0.69 ms) have ever been synthesized (as of 2020 [3]).
The weight of the first-generation iPad varied, dependent upon the connectivity options chosen. The Wi-Fi only variant weighs 1.5 lb (680 g) whereas the variant with Wi-Fi + 3G weighs 1.6 lb (730 g). [2] Its dimensions, however, are identical across the entire range of variants, measuring 9.56×7.47×0.5 in (243×190×13 mm). [2]