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GLP-1 agonists are a class of medications that mimic the action of the hormone GLP-1 (glucagon-like peptide-1), which is involved in insulin production and appetite regulation. “GLP-1 stands for ...
Well, semaglutide is a glucagon-like peptide 1 (GLP-1) receptor agonist. It mimics the GLP-1 hormone, ... The dose can then increase in 2.5-milligram increments after at least four weeks, up to a ...
Like Ozempic, Wegovy is a glucagon-like peptide-1 (GLP-1) receptor agonist and it has the same active ingredient: ... It contains a higher dose of semaglutide and it’s FDA-approved for weight loss.
In accordance with the expression of GLP-1 receptor on brainstem and hypothalamus, GLP-1 has been shown to promote satiety and thereby reduce food and water intake. Consequently, diabetic subjects treated with GLP-1 receptor agonists often experience weight loss as opposed to the weight gain commonly induced with other treatment agents. [2] [15]
These drugs are developed for the same indications as GLP-1 receptor agonists—especially obesity, type 2 diabetes, and non-alcoholic fatty liver disease. They are expected to provide superior efficacy with fewer adverse effects compared to GLP-1 mono-agonists, which are dose-limited by gastrointestinal disturbances. [2]
In December 2024, Novo Nordisk announced the results of REDEFINE 1, one of their series of Phase III trials, testing weekly cagrilintide 2.4 mg and semaglutide 2.4 mg individually and together versus placebo in obese or overweight subjects with one or more comorbidities. [7]
Semaglutide is a glucagon-like peptide-1 receptor agonist. It works by mimicking GLP-1 hormone, which is naturally produced in your intestines. It works by mimicking GLP-1 hormone, which is ...
A large study of more than 2 million people evaluated benefits and risks of GLP-1 agonists. The study showed that GLP-1 agonists reduced risk of substance use and psychotic disorders, seizures, neurocognitive disorders (including Alzheimer’s disease and dementia), coagulation disorders, cardiometabolic disorders, infectious illnesses and several respiratory conditions [5].