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His fluid magnesia product was patented two years after his death, in 1873. [15] The term milk of magnesia was first used by Charles Henry Phillips in 1872 for a suspension of magnesium hydroxide formulated at about 8% w/v. [16] It was sold under the brand name Phillips' Milk of Magnesia for medicinal usage.
Phillips produced milk of magnesia and other pharmaceuticals at his Glenbrook firm, which incorporated in 1885 as the Charles H. Phillips Company.After Phillips' death of apoplexy in New York on 29 October 1888, [4] his four sons ran the corporation until 1923, when it was acquired by Sterling Drug, Inc.
However it is insoluble in water. Insoluble magnesium salts such as magnesium oxide or magnesium hydroxide (milk of magnesia) depend on stomach acid for neutralization before they can be absorbed, and thus are relatively poor oral magnesium sources, on average. Magnesium sulfate (Epsom salts) is soluble in water.
The structures of solid magnesium citrates have been characterized by X-ray crystallography.In the 1:1 salt, only one carboxylate of citrate is deprotonated. It has the formula Mg(H 2 C 6 H 5 O 7) 2 The other form of magnesium citrate has the formula Mg(HC 6 H 5 O 7)(H 2 O) 2, consisting of the citrate dianion (both carboxylic acids are deprotonated). [1]
Sir James Murray. Sir James Murray (1788–1871) was an Irish physician, whose research into digestion led to his discovery of the stomach aid Milk of Magnesia in 1809. He later studied in electrotherapy and led the research into the causes of cholera and other epidemics as a result of exposure to natural electricity.
For other than pregnancy-related hypertension, a meta-analysis of 22 clinical trials with dose ranges of 120 to 973 mg/day and a mean dose of 410 mg, concluded that magnesium supplementation had a small but statistically significant effect, lowering systolic blood pressure by 3–4 mm Hg and diastolic blood pressure by 2–3 mm Hg.