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Phenibut is used in Russia, Ukraine, Belarus and Latvia as a pharmaceutical drug to treat anxiety and to improve sleep (e.g., in the treatment of insomnia). [5] [6] It is also used for various other indications, including the treatment of asthenia, depression, alcoholism, alcohol withdrawal syndrome, post-traumatic stress disorder, stuttering, tics, vestibular disorders, Ménière's disease ...
The drug is a GABA analogue and is closely related to baclofen (β-(4-chlorophenyl)-GABA), tolibut (β-(4-methylphenyl)-GABA), and phenibut (β-phenyl-GABA). [1] It is less potent as a GABA B receptor agonist than baclofen but more potent than phenibut.
In one study, the affinity (K i) values of gabapentinoids for the α 2 δ subunit expressed in rat brain were found to be 0.05 μM for gabapentin, 23 μM for (R)-phenibut, 39 μM for (S)-phenibut, and 156 μM for baclofen. [9] Their affinities (K i) for the GABA B receptor were >1 mM for gabapentin, 92 μM for (R)-phenibut, >1 mM for (S)-phenibut.
The truth is, most things aren't actually all that bad for you if you take them in moderation. Prepare to rejoice and check out the round-up gallery above for 10 supposedly bad things that are ...
Phenibut (Anvifen, Fenibut, Noofen) is an anxiolytic [42] used in Russia. [43] Phenibut is a GABA B receptor agonist , [ 42 ] as well as an antagonist at α 2 δ subunit -containing voltage-dependent calcium channels (VDCCs), similarly to gabapentinoids like gabapentin and pregabalin . [ 44 ]
Amino acid supplements help you create and maintain muscle. Many people consume amino acids to support growth in muscle mass and strength. But get this: ...
Image credits: debdeman #6. Not me but my mother. My mom bought the travel insurance on her Disneyworld trip because she is bipolar and thought if she had a bad day they would get a refund.
Tolibut, also known as 3-(p-tolyl)-4-aminobutyric acid (or β-(4-methylphenyl)-GABA), is drug that was developed in Russia.It is an analogue of γ-aminobutyric acid (GABA) and is the 4-methyl analogue of phenibut, and is also an analogue of baclofen where the 4-chloro substitution has been replaced with a 4-methyl substitution.