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Side effects from ketoconazole are rare. In the 2019 study we mentioned earlier comparing ketoconazole shampoo to minoxidil, only 10 percent of people reported side effects from ketoconazole.
Ketoconazole shampoo in conjunction with an oral 5α-reductase inhibitor such as finasteride or dutasteride has been used off label to treat androgenic alopecia. It was speculated that antifungal properties of ketoconazole reduce scalp microflora and consequently may reduce follicular inflammation that contributes to alopecia.
Oral ketoconazole has side effects too. In 2016, the FDA (U.S. Food and Drug Administration) limited the use of Nizoral oral tablets due to a potential risk of liver and adrenal damage.
Specifically, ketoconazole or ciclopirox are effective. [10] Seborrhoeic dermatitis of the scalp is often treated with shampoo preparations of ketoconazole zinc pyrithione, and selenium, although the latter has been partly discontinued due to concerns of selenium in higher concentrations being carcinogenic. [11]
Ketoconazole appears to have a longer duration of effect. [9] Ketoconazole is a broad-spectrum antimycotic agent that is active against Candida and M. furfur. Of all the antifungals of the imidazole class, ketoconazole has become the leading contender among treatment options because of its effectiveness in treating seborrheic dermatitis as well ...
Cerulla also likes this drugstore shampoo, which is formulated with 1 percent ketoconazole to fight dandruff. Nizoral can help control the fungus on your scalp, says the brand, and cut down on ...
Other options include topical or systemic spironolactone or flutamide, although they have a high incidence of feminising side effects and are better tolerated in female androgenic hair loss. More advanced cases may be resistant or unresponsive to medical therapy, however, and require hair transplantation .
[15] [16] Based on the study, the systematic review concluded that selenium disulfide may be effective in the treatment of dandruff but that the available evidence is limited and overall evidence quality is low. [15] It also found that while selenium disulfide has infrequent side effects, it seems to have more side effects than ketoconazole ...