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TRIzol is a widely used [1] chemical solution used in the extraction of DNA, RNA, and proteins from cells. The solution was initially used and published by Piotr Chomczyński and Nicoletta Sacchi in 1987.
Azelis Group is a Belgium-based distributor specializing in food ingredients and specialty chemicals, headquartered in Antwerp. [ 1 ] [ 2 ] It is listed on Euronext since 2021 and has presence in Europe, the Middle East and Africa, Asia-Pacific, and the Americas.
VWR was founded by John Taylor as the John Taylor Company in 1852, selling mining and laboratory products. [7] Since then, the company evolved to focus on the laboratory market. It also has a presence in the cleanroom, safety, and clinical markets. In 1902, it was purchased by F.W. Braun, and merged into his company the F.W. Braun Corporation. [8]
Chemical & Engineering News publishes an annual list of the world's largest chemical producers by sales, excluding formulated products such as pharmaceutical drugs and coatings. [1] In 2018, sales of the top fifty companies amounted to US$ 951,000,000,000, an increase of 11.8% compared to the top fifty producers of 2017. [ 2 ]
Other denaturing chemicals such as 2-mercaptoethanol and sarcosine may also be used. The major downside is that phenol and chloroform are both hazardous and inconvenient materials, and the extraction is often laborious, so in recent years many companies now offer alternative ways to isolate RNA.
Flavor-wise and chemical-wise, Spindrift gets some of the highest marks, with 0.19 ppt PFAS, or parts per trillion ("safe" PFAS levels are seen as being below 1 ppt).
Brenntag SE is the holding company of Brenntag Group. The company was founded in 1874 in Berlin and specializes in the distribution of chemicals and ingredients. The company is headquartered in Essen, Germany and has operations in more than 600 locations in 72 countries. [2]
Guanidinium thiocyanate can be used to deactivate a virus, such as the influenza virus that caused the 1918 "Spanish flu", so that it can be studied safely.. Guanidinium thiocyanate is also used to lyse cells and virus particles in RNA and DNA extractions, where its function, in addition to its lysing action, is to prevent activity of RNase enzymes and DNase enzymes by denaturing them.