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The symptoms seen with the interaction vary from medication to medication — the symptoms are not from the grapefruit. They're from the medication." ... "Many food-drug interactions and potential ...
Analgesic and behavioral effects were reported for 12 hours and plasma samples were analyzed for oxycodone metabolites for 48 hours. Grapefruit juice increased the mean area under the oxycodone concentration-time curve (AUC(0-∞)) by 1.7 fold, the peak plasma concentration by 1.5-fold and the half-life of oxycodone by 1.2-fold as compared to ...
Statins to lower cholesterol, such as Lipitor (atorvastatin) and Zocor (simvastatin) Certain antihistamines, like Allegra (fexofenadine) Medications to treat high blood pressure, such as Procardia ...
Important: If you're taking statins or medications for conditions like high blood pressure, cholesterol, heart arrhythmia, organ transplants, or allergies, it can be dangerous to eat grapefruit.
Grapefruit juice components are known inhibitors of intestinal CYP3A4. Drinking grapefruit juice with atorvastatin may cause an increase in C max and area under the curve (AUC). This finding initially gave rise to concerns of toxicity, and in 2000, it was recommended that people taking atorvastatin should not consume grapefruit juice "in an ...
The effect of grapefruit juice with regard to drug absorption was originally discovered in 1989. The first published report on grapefruit drug interactions was in 1991 in the Lancet entitled "Interactions of Citrus Juices with Felodipine and Nifedipine", and was the first reported food-drug interaction clinically. The effects of grapefruit last ...
As with atorvastatin, simvastatin, and other statin drugs metabolized via CYP3A4, drinking grapefruit juice during lovastatin therapy may increase the risk of side effects. Components of grapefruit juice, the flavonoid naringin, or the furanocoumarin bergamottin inhibit CYP3A4 in vitro, [13] and may account for the in vivo effect of grapefruit ...
At a serving size of half a medium grapefruit, you’ll have 60 calories (zero from fat), 100 percent of your vitamin C requirement for the day, no sodium or cholesterol, 15 grams of carbohydrates ...