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This longer duration of action also means vardenafil could be a good choice if you like to perform twice a night. Second, it starts working quickly, with research suggesting it kicks in after less ...
Here’s a list of both the half-lives and duration of action for four of the most common ED drugs (PDE5 inhibitors): ... Vardenafil. The active ingredient in Levitra, vardenafil can provide ...
The difference between the vardenafil molecule and sildenafil citrate is a nitrogen atom's position and the change of sildenafil's piperazine ring methyl group to an ethyl group. Tadalafil is structurally different from both sildenafil and vardenafil. Vardenafil's relatively short effective time is comparable to but somewhat longer than ...
Although sildenafil, vardenafil, and tadalafil all work by inhibiting PDE5, tadalafil's pharmacologic distinction is its longer half-life (17.5 hours), [21] compared to sildenafil and vardenafil, which are both 4–5 hours. [22] This translates to a longer duration of action, which is partly responsible for "The Weekend Pill" nickname.
This allows for a longer therapeutic window and is therefore often a more convenient drug than others with a shorter therapeutic window. Tadalafil is more bioavailable (80%) than sildenafil (40%) and vardenafil (15%) but it has a slow absorption, or about 2 hours compared to 50 minutes of sildenfil. Vardenafil is most known for its potency. [24]
Brand-name ED drugs like Cialis (tadalafil), Levitra(vardenafil), Stendra and others that are FDA-approved to treat ED are also not safe to use without medical advice.
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