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Interleukin 3 (IL3) is a cytokine that regulates hematopoiesis by controlling the production, differentiation and function of granulocytes and macrophages. [ 15 ] [ 16 ] The protein, which exists in vivo as a monomer, is produced in activated T cells and mast cells, [ 15 ] [ 16 ] and is activated by the cleavage of an N-terminal signal sequence.
The IL-10 family is one of the important types of cytokines, that can stop the inflammation. In general. these cytokines have a helical structure of homodimers. [4] The difference that the members of IL-10 family have between each other is that they have various receptor-binding residues, which help with interaction with specific cytokine receptors. [5]
Interleukin-15 (IL-15) is a protein that in humans is encoded by the IL15 gene. IL-15 is an inflammatory cytokine with structural similarity to Interleukin-2 (IL-2). Like IL-2, IL-15 binds to and signals through a complex composed of IL-2/IL-15 receptor beta chain ( CD122 ) and the common gamma chain (gamma-C, CD132).
Interleukin 10 (IL-10), also known as human cytokine synthesis inhibitory factor (CSIF), is an anti-inflammatory cytokine. In humans, interleukin 10 is encoded by the IL10 gene. [ 5 ] IL-10 signals through a receptor complex consisting of two IL-10 receptor-1 and two IL-10 receptor-2 proteins. [ 6 ]
Cytokine receptor common subunit gamma also known as interleukin-2 receptor subunit gamma or IL-2RG is a protein that in humans is encoded by the IL2RG gene. [8] The human IL2RG gene is located on the long (q) arm of the X chromosome at position 13.1, from base pair 70,110,279 to base pair 70,114,423.
16878 Ensembl ENSG00000128342 ENSMUSG00000034394 UniProt P15018 P09056 RefSeq (mRNA) NM_001257135 NM_002309 NM_001039537 NM_008501 RefSeq (protein) NP_001244064 NP_002300 NP_001034626 NP_032527 Location (UCSC) Chr 22: 30.24 – 30.25 Mb Chr 11: 4.21 – 4.22 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Leukemia inhibitory factor, or LIF, is an interleukin 6 class cytokine that ...
IL-12 binds to the IL-12 receptor, which is a heterodimeric receptor formed by IL-12Rβ1 and IL-12Rβ2. [6] IL-12Rβ2 is considered to play a key role in IL-12 function, since it is found on activated T cells and is stimulated by cytokines that promote Th1 cells development and inhibited by those that promote Th2 cells development.
Alpha-taxilin also known as interleukin-14 (IL-14) or high molecular weight B-cell growth factor (HMW-BCGF) is a protein that in humans is encoded by the TXLNA gene. [5] [6] [7] Interleukin-14 is a cytokine that controls the growth and proliferation of both normal and cancerous B cells. [8] This molecule was also recently designated taxilin. [9]