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MAC is used to compare the strengths, or potency, of anaesthetic vapours. [1] The concept of MAC was first introduced in 1965. [2] MAC actually is a median value, not a minimum as term implies. The original paper proposed MAC as the minimal alveolar concentration, [3] which was shortly thereafter revised to minimum alveolar concentration. [4]
Although other drugs, such as azithromycin and clarithromycin, have laboratory and clinical activity against MAC, none has been shown in a prospective, controlled trial to be effective and safe for prophylaxis. Thus, in the absence of data, no other regimen can be recommended at this time. The 300-mg dose of rifabutin has been well tolerated.
Azithromycin, sold under the brand names Zithromax (in oral form) and Azasite (as an eye drop), is an antibiotic medication used for the treatment of several bacterial infections. [10] This includes middle ear infections , strep throat , pneumonia , traveler's diarrhea , and certain other intestinal infections . [ 10 ]
The therapeutic index (TI; also referred to as therapeutic ratio) is a quantitative measurement of the relative safety of a drug with regard to risk of overdose.It is a comparison of the amount of a therapeutic agent that causes toxicity to the amount that causes the therapeutic effect. [1]
β-Lactam antibiotics are indicated for the prevention and treatment of bacterial infections caused by susceptible organisms. At first, β-lactam antibiotics were mainly active only against gram-positive bacteria, yet the recent development of broad-spectrum β-lactam antibiotics active against various gram-negative organisms has increased their usefulness.
The Double Big Mac, consisting of four patties and three pieces of bread, takes the regular Big Mac to another level. Of the five tasters, we gave it a 3.5/5 average rating.
Azithromycin is a macrolide commonly used in bronchiectasis. Antibiotics are used in bronchiectasis to eradicate P. aeruginosa or MRSA, to suppress the burden of chronic bacterial colonization, and to treat exacerbations. [3] The use of daily oral non-macrolide antibiotic treatment has been studied in small case series, but not in randomized ...
Narrow-spectrum antibiotics have low propensity to induce bacterial resistance and are less likely to disrupt the microbiome (normal microflora). [3] On the other hand, indiscriminate use of broad-spectrum antibiotics may not only induce the development of bacterial resistance and promote the emergency of multidrug-resistant organisms, but also cause off-target effects due to dysbiosis.
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