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Estroven is a dietary supplement, first produced in 1997, used to treat the effects of hormonal imbalance in women during all stages of menopause. Estroven contains a standardized extract of black cohosh ( Cimicifuga racemosa ) and plant-based estrogens (called isoflavones ) from soy , both used to help reduce hot flashes and night sweats .
Original file (1,650 × 1,275 pixels, file size: 128 KB, MIME type: application/pdf) This is a file from the Wikimedia Commons . Information from its description page there is shown below.
For comparison, the bioavailability of oral estradiol is around 5%. [10] The estradiol levels that result with typical clinical doses of estradiol and estradiol esters by intramuscular injection tend to be high compared to the typical estradiol levels that occur with other clinically used routes and forms of estradiol. [10] [16] [273] [274] [13
For comparison, the metabolic clearance rate of estriol is 1,110 L/day/m 2. [5] A single 1 to 2 mg dose of estrone in oil solution by intramuscular injection has a duration of about 2 or 3 days. [ 45 ] [ 67 ] [ 68 ] As an aqueous suspension by intramuscular injection , estrone was used at a dose of 0.1 to 0.5 mg 2 to 3 times per week, or at a ...
Antiestrogens include selective estrogen receptor modulators (SERMs) like tamoxifen, clomifene, and raloxifene, the ER silent antagonist and selective estrogen receptor degrader (SERD) fulvestrant, [6] [7] aromatase inhibitors (AIs) like anastrozole, and antigonadotropins including androgens/anabolic steroids, progestogens, and GnRH analogues.
The four major naturally occurring estrogens in women are estrone (E1), estradiol (E2), estriol (E3), and estetrol (E4). Estradiol (E2) is the predominant estrogen during reproductive years both in terms of absolute serum levels as well as in terms of estrogenic activity.