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Doxylamine is used in the combination drug pyridoxine/doxylamine to treat morning sickness (nausea and vomiting of pregnancy). [ 19 ] [ 20 ] [ 21 ] It is the only medication approved by the United States Food and Drug Administration for the treatment of morning sickness.
Pyridoxine/doxylamine, sold under the brand name Diclectin among others, is a combination of pyridoxine hydrochloride (vitamin B 6) and doxylamine succinate.It is generally used for nausea and vomiting of pregnancy (morning sickness); even though its efficacy has not been proven and subsequent research has led to the removal of recommendations in medical journals.
She died in 1855 while four months pregnant, having been affected by intractable nausea and vomiting throughout her pregnancy, and was unable to tolerate food or even water. [50] Catherine, Princess of Wales was hospitalised due to hyperemesis gravidarum during her first pregnancy, and was treated for the same condition during the subsequent two.
Nausea can be caused by weight loss drugs, pregnancy, food poisoning, migraines. Doctors share home remedies for nausea, including ginger and peppermint.
Morning sickness affects about 70–80% of all pregnant women to some extent. [4] [5] About 60% of women experience vomiting. [2] Hyperemesis gravidarum occurs in about 1.6% of pregnancies. [1] Morning sickness can negatively affect quality of life, result in decreased ability to work while pregnant, and result in health-care expenses. [3]
The exact cause of morning sickness remains unknown. Nausea and vomiting in pregnancy is typically mild and self-limited, resolving on its own by the 14th week of pregnancy. Other causes should also be ruled out when considering treatment. Initial treatment is typically conservative, and may include changes to diet and emotional support.
Nausea or "morning sickness" is common during early pregnancy but may occasionally continue into the second and third trimesters. In the first trimester nearly 80 % of women have some degree of nausea. [9] Pregnancy should therefore be considered as a possible cause of nausea in any sexually active woman of child-bearing age. [8]
Pregnancy Sickness Support was registered as a Charitable Trust in 2002 by founders Dr. Anthony Barnie-Adshead, his daughter Caroline Adshead and Dr. Roger Gadsby. Dr. Barnie-Adshead had become interested in pregnancy sickness and hyperemesis gravidarum in the 1960s during his career as a GP and initiated novel research trying to find the