Search results
Results From The WOW.Com Content Network
A transcriptome-wide analysis in mice found that a protein-restricted (PR) diet during gestation resulted in differential gene expression in approximately 1% of the fetal genes analyzed (235/22,690). Specifically, increased expression was seen in genes involved in the p53 pathway, apoptosis , negative regulators of cell metabolism, and genes ...
Nutritional genomics, also known as nutrigenomics, is a science studying the relationship between human genome, human nutrition and health. People in the field work toward developing an understanding of how the whole body responds to a food via systems biology, as well as single gene/single food compound relationships.
Furthermore, nutrition can affect methylation as the process continues throughout an individual’s adult life. Because of this, nutritional epigeneticists have studied food as a form of molecular exposure. [1] DNA methylation is the addition of a methyl group on a cytosine ring of DNA. [15]
Gene-set analysis (for example using tools like DAVID and GoSeq) has been shown to be severely biased when applied to high-throughput methylation data (e.g. genome-wide bisulfite sequencing); it has been suggested that this can be corrected using sample label permutations or using a statistical model to control for differences in the numberes ...
Differentially methylated regions (DMRs) are genomic regions with different DNA methylation status across different biological samples and regarded as possible functional regions involved in gene transcriptional regulation. The biological samples can be different cells/tissues within the same individual, the same cell/tissue at different times ...
These DNA methyltransferases can also methylate CpG sites within the coding regions of genes, where such methylation can increase gene transcription. [34] Work with DNMT3a1 showed it preferentially localized to CpG islands bivalently marked by H3K4me3 (a transcription promoting mark) and H3K27me3 (a transcription repressive mark), coinciding ...
The modification may also occur at other sites, [4] but methylation at either of these sites can repress gene expression by either interfering with the binding of transcription factors or modifying chromatin structure to a repressive state. [5] Disease condition studies have largely fueled the effort in understanding the role of DNA methylation.
68023 Ensembl ENSG00000258429 ENSMUSG00000078931 UniProt Q9HBH1 S4R2K0 RefSeq (mRNA) NM_022341 NM_026513 RefSeq (protein) NP_071736 NP_080789 Location (UCSC) Chr 16: 69.33 – 69.33 Mb Chr 8: 107.77 – 107.78 Mb PubMed search Wikidata View/Edit Human View/Edit Mouse Peptide deformylase, mitochondrial is an enzyme that in humans is encoded by the PDF gene. References ^ a b c GRCh38: Ensembl ...