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Phenoxyethanol has germicidal and germistatic properties. [6] It is often used together with quaternary ammonium compounds.. Phenoxyethanol is used as a perfume fixative; an insect repellent; an antiseptic; [7] a solvent for cellulose acetate, dyes, inks, and resins; a preservative for pharmaceuticals, cosmetics and lubricants; [8] an anesthetic in fish aquaculture; [9] [10] and in organic ...
In drug development and medical device development [1] the Investigator's Brochure (IB) is a comprehensive document summarizing the body of information about an investigational product ("IP" or "study drug") obtained during a drug trial. The IB is a document of critical importance throughout the drug development process and is updated with new ...
A patch test relies on the principle of a type IV hypersensitivity reaction.. The first step in becoming allergic is sensitization. When skin is exposed to an allergen, the antigen-presenting cells (APCs) – also known as Langerhans cell or Dermal Dendritic Cell – phagocytize the substance, break it down to smaller components and present them on their surface bound major histocompatibility ...
p-Phenylenediamine (PPD) is an organic compound with the formula C 6 H 4 (NH 2) 2. This derivative of aniline is a white solid, but samples can darken due to air oxidation. [ 1 ] It is mainly used as a component of engineering polymers and composites like kevlar .
In drug development, preclinical development (also termed preclinical studies or nonclinical studies) is a stage of research that begins before clinical trials (testing in humans) and during which important feasibility, iterative testing and drug safety data are collected, typically in laboratory animals.
Toxicology testing is commonly conducted during preclinical development for a substance intended for human exposure. Stages of in silico, in vitro and in vivo research are conducted to determine safe exposure doses in model organisms. If necessary, the next phase of research involves human toxicology testing during a first-in-man study.
The first appearance of the term ‘safety pharmacology’ in the published literature dates back to 1980. [5] The term was certainly in common usage in the 1980s within the pharmaceutical industry to describe nonclinical pharmacological evaluation of unintended effects of candidate drugs for regulatory submissions. [6]
Refers to the practices and procedures used for the prevention, treatment, or relief of symptoms of a diseases or abnormal conditions. This term may also refer to a legal drug used for the same purpose. (NCI) Meta-analysis The formal evaluation of the quantitative evidence from two or more trials bearing on the same question.
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