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Bilastine distribution has an apparent volume of distribution of 1.29 L/kg, and has an elimination half-life of 14.5 h and plasma protein binding of 84–90%. [26] Bilastine is a peripherally selective drug, and this is thought to be due to limited brain uptake caused by binding to P-glycoprotein. [27] [28]
Chitinases are also present in plants – for example barley seed chitinase: EC 3.2.1.14. Barley seeds are found to produce clone 10 in Ignatius et al 1994(a). They find clone 10, a Class I chitinase, in the seed aleurone during development. [5] [6] [7] Leaves produce several isozymes (as well as several of β-1,3-glucanase).
The pharmacokinetics of cetirizine have been found to increase linearly with dose across a range of 5 to 60 mg. [9] Its C max following a single dose has been found to be 257 ng/mL for 10 mg and 580 ng/mL for 20 mg. [8] Food has no effect on the bioavailability of cetirizine but has been found to delay the T max by 1.7 hours (i.e., to ...
Antihistamines are drugs which treat allergic rhinitis, common cold, influenza, and other allergies. [1] Typically, people take antihistamines as an inexpensive, generic (not patented) drug that can be bought without a prescription and provides relief from nasal congestion, sneezing, or hives caused by pollen, dust mites, or animal allergy with few side effects. [1]
Chitinase-3-like protein 1 (CHI3L1), also known as YKL-40, is a secreted glycoprotein that is approximately 40kDa in size that in humans is encoded by the CHI3L1 gene. [ 5 ] [ 6 ] [ 7 ] The name YKL-40 is derived from the three N-terminal amino acids present on the secreted form and its molecular mass .
The original formula for Actifed contained pseudoephedrine hydrochloride 60 mg as the nasal decongestant and triprolidine hydrochloride 2.5 mg as the antihistamine. . However, in response to widespread laws requiring products containing pseudoephedrine to be kept behind the pharmacy counter, Pfizer changed Actifed's U.S. formula in late 2006 to contain phenylephrine HCl 10 mg as the nasal ...
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