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PP2 is a substance that has frequently been used in cancer research as a "selective" inhibitor for Src-family kinases. It strongly inhibits the kinases Lck ( IC 50 =4 nM ), Fyn (5 nM) and Hck (5 nM), shows weaker inhibition of EGFR (480 nM) and practically no inhibition of ZAP-70 (100 μM) and JAK2 (50 μM).
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Image source: The Motley Fool. BioCryst Pharmaceuticals (NASDAQ: BCRX) Q4 2024 Earnings Call Feb 24, 2025, 8:30 a.m. ET. Contents: Prepared Remarks. Questions and Answers. Call Participants
Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. [ 2 ] [ 3 ] The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity in eukaryotic cells. [ 4 ]
A remove before flight ribbon on Concorde landing gear A remove before flight keychain. Remove before flight is a safety warning often seen on removable aircraft and spacecraft components, typically in the form of a red ribbon, to indicate that a device, such as a protective cover or a pin to prevent the movement of mechanical parts, is only used when the aircraft is on the ground (parked or ...
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On August 2, 2004, Remy was charged with vandalism after McMahon found him cutting up her clothes and pictures with scissors. [1] [4] He was released on a $500 bail with the agreement of the prosecutors who insisted that Remy should find a job. Remy was hired by the Red Sox to work as a security guard at Fenway Park. [2]