Search results
Results From The WOW.Com Content Network
The β-lactam core structures. (A) A penam.(B) A carbapenam.(C) An oxapenam.(D) A penem.(E) A carbapenem.(F) A monobactam.(G) A cephem.(H) A carbacephem.(I) An oxacephem. This is a list of common β-lactam antibiotics—both administered drugs and those not in clinical use—organized by structural class.
β-Lactam antibiotics are indicated for the prevention and treatment of bacterial infections caused by susceptible organisms. At first, β-lactam antibiotics were mainly active only against gram-positive bacteria, yet the recent development of broad-spectrum β-lactam antibiotics active against various gram-negative organisms has increased their usefulness.
A lactam is a cyclic amide, and beta-lactams are named so because the nitrogen atom is attached to the β-carbon atom relative to the carbonyl. The simplest β-lactam possible is 2-azetidinone. β-lactams are significant structural units of medicines as manifested in many β-lactam antibiotics. [2]
Main page; Contents; Current events; Random article; About Wikipedia; Contact us
The allergy does not commonly persist into adolescence. Gluten-free foods are safer for wheat allergic patients but they still may theoretically contain wheat's other allergenic proteins. [61] Wheat allergy symptoms should not be confused with celiac disease, gluten ataxia or non-celiac gluten sensitivity (NCGS).
Lactamization is most efficient in this way if the product is a γ-lactam. For example, Fmoc-Dab(Mtt)-OH, although its side-chain amine is sterically protected by extremely bulky 4-Methyltrityl (Mtt) group, the amine can still intramolecularly couple with the carboxylic acid to form a γ-lactam.
Main page; Contents; Current events; Random article; About Wikipedia; Contact us; Pages for logged out editors learn more
The β-lactam ring is not fused to another ring, in contrast to most other β-lactams. [ 1 ] Monobactams are narrow-spectrum antibiotics [ 2 ] effective only against (strictly or facultatively [ 3 ] ) aerobic Gram-negative bacilli , [ 4 ] [ 5 ] [ 3 ] exhibiting a high level of resistance to beta-lactamases of these organisms. [ 3 ]