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It is still unknown what causes interstitial lung disease associated with antisynthetase syndrome. [5] Many antisynthetase antibodies have been reported with anti-Jo1 being the most prevalent. [ 6 ] Pulmonary involvement is an important factor of morbidity and mortality with Antisynthetase syndrome, affecting 70–100% of patients.
The term "usual" refers to the fact that UIP is the most common form of interstitial fibrosis. "Pneumonia" indicates "lung abnormality", which includes fibrosis and inflammation.
Interstitial lung disease (ILD), or diffuse parenchymal lung disease (DPLD), [3] is a group of respiratory diseases affecting the interstitium (the tissue) and space around the alveoli (air sacs) of the lungs. [4] It concerns alveolar epithelium, pulmonary capillary endothelium, basement membrane, and perivascular and perilymphatic tissues. It ...
These patients were all heavy smokers and considered to have a form of interstitial lung disease. Most were in their 40s and had abnormalities in pulmonary function tests, most commonly reduced diffusion capacity for carbon monoxide (DLCO). Their symptoms generally remained stable (did not worsen) over up to 10 years of follow-up. [7]
The Common Technical Document (CTD) is a set of specifications for an application dossier for the registration of medicine, designed for use across Europe, Japan, the United States, and beyond. [ 1 ] Major Synopsis
In the 1980s, the European Union began harmonising regulatory requirements. In 1989, Europe, Japan, and the United States began creating plans for harmonisation. The International Conference on Harmonisation of Technical Requirements for Registration of Pharmaceuticals for Human Use (ICH) was created in April 1990 at a meeting in Brussels.
ACR Education Center – located in Reston, VA, offers specialized mini-fellowships in more than a dozen clinical areas. [3]American Institute for Radiologic Pathology (AIRP) – The AIRP conducts five courses for radiology residents and fellows, and seven categorical courses for practicing radiologists and other physicians each year in Silver Spring, MD.
ACR score is a scale to measure change in rheumatoid arthritis symptoms. [1] It is named after the American College of Rheumatology. The ACR score is more often used in clinical trials than in doctor patient-relationships, as it allows a common standard between researchers. Different degrees of improvement are referred to as ACR20, ACR50, ACR70.
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